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Coutavas E, Ren M, Oppenheim JD et al (1993) Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

As a proxy for neuronal activity, neurons were exposed to anti-Syt1 lumenal primary antibody directly labeled with ATTO647N (1:200, 105 311AT1 clone 604.2 Synaptic Systems) in conditioned medium for 30 mins at 37 C

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MMP9 inhibition prevented NF-KB activation and restored PVIN/PNN integrity, linking redox-controlled MMP9 to excitatory/inhibitory imbalance ( In the brain, the major regulator of redox status is GSH, which has also been shown to regulate inflammation